消化性潰瘍疾患または消化管出血の既往がある場合、PPI または H2 ブロッカーを併用せずに、COX-2 非選択的非ステロイド性抗炎症薬(NSAIDs)を使用することは推奨しない（消化性潰瘍再発のリスク）。
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